• April 22 - Battle of Bicocca[?] - French and Swiss forces under Odet de Lautrec[?] are defeated by the Spanish in their attempt to retake Milan, and are forced to withdraw into Venetian territory.
• July 28 - Beginning of Ottoman Sultan Suleiman I's siege of the Knights of St. John in Rhodes.
• December 18 - The Turks finally break into Rhodes, but the Knights continue fierce resistance in the streets
• December 20 - Suleiman accepts the surrender of the surviving Knights, who are allowed to evacuate. They eventually re-settle on Malta and become known as the Knights of Malta.
• First Diet of Nuremberg
• Adrian Dedens becomes Pope Adrian VI
• Battle of La Bicoca[?]

Births

• March 28 - Albert The Warlike

Deaths