• January 3 - Pope Leo X excommunicates Martin Luther.
• January 28 - Diet of Worms begins, lasting until May 25.
• March 6 - Ferdinand Magellan discovers Guam
• March 16 - Ferdinand Magellan reaches the Philippines.
• April 27 - Battle of Mactan: Explorer Ferdinand Magellan is killed by natives in the Philippines.
• May - Outbreak of war between Emperor Charles and the King of France.
• May 20 - Battle of Pampeluna[?]
• May 25 - The Diet of Worms ends when Charles V, Holy Roman Emperor issues the Edict of Worms, declaring Martin Luther an outlaw[?].
• June 30 - Battle of Esquiroz[?] - French forces under Henri d'Albret[?], exiled King of Navarre, are defeated by the Spanish and forced to abandon their attempt to recover Henri's kingdom.
• August 29 - Capture of Belgrade by the Turkish army of Suleiman I after a brave resistance.
• November 23 - Spanish-German-Papal forces under Prosper Colonna[?] force French Marshal Odet de Lautrec[?] to abandon Milan.
• The Turks occupy Belgrade
• Cuautemoc, the last Aztec Emperor, surrenders to Spanish Conquistador Hernan Cortes

Births

• May 8 - Petrus Canisius[?], Jesuit (+ 1597)

Deaths

• April 17 - Ferdinand Magellan, Portuguese explorer