• March - With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I.
• July - Selim I of the Ottoman Empire declares war on the Mameluks and invades Syria.
• August 13 - Treaty of Noyon[?] - Peace between France and Spain. Francis recognizes Charles's claim to Naples, and Charles recognizes Francis's claim to Milan.
• August 24 - Battle of Merj-Dabik[?]. The Ottomans defeat the Mameluks, who abandon Syria.
• October 28 - Battle of Yaunis Khan[?]. Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza.
• December 4 - Treaty of Brussels[?] - Peace between France and the Empire.

Births

• February 18 - Queen Mary I of England (+ 1558)

Deaths

• 23 January - Ferdinand II of Aragon