• June - Invasion of Persia by Sultan Selim I of the Ottoman Empire.
• August 23 - Battle of Chaldiran[?]. Selim I crushes the Persian army of Shah Ismail I[?].
• September 5 - Selim captures the Persian capital of Tabriz[?] without encountering any resistance, but is unable to hold it.
• September 13 - September 14 - Battle of Marignano[?] - The army of Francis I of France defeats the Swiss, thanks to the timely arrival of a Venetian army. Francis restores French control of Milan
• Sweden declared indepedence
• Ottoman Empire conquers Kurdistan

Births

• September 22 - Anne of Cleves, later fourth Queen consort of Henry VIII of England.
• November 20 - Mary of Guise, later Queen consort of James V of Scotland and Regent for her daughter Mary I of Scotland.

Deaths

• January 1 - King Louis XII of France
• December 1 - Hernandez Gonzalo de Cordoba[?], "El Gran Capitan", Spanish General.
• Alphonso d'Albuquerque, Portuguese naval general
• Mariotto Albertinelli, Italian painter
• Nezahualpilli[?] of Texcoco, Aztec philosopher