• January 5 - Duke Ludovico Sforza recaptures Milan, but is soon driven out again by the French
• January 26 - Vicente Yáñez Pinzón[?] become the first European to discover Brazil.
• April 22 - Portuguese navigator Pedro Alvares Cabral becomes the first European to sight Brazil.
• November 11 - Treaty of Granada[?] - Louis XII of France and Ferdinand II of Aragon agree to divide the Kingdom of Naples between them.
• Pedro Alvares Cabral claims Brazil for Portugal
• Emperor Go-Kashiwabara ascends to the throne of Japan
• Battle of Hemmingstedt: The Danish army fails to conquer the peasants' republic of Dithmarschen
• Second Battle of Lepanto[?] - The Turkish fleet of Kemal Re'is defeats the Venetians. The Turks proceed to capture Modon, Lepanto, and Koron.

Births

• February 24 - Charles V of Hapsburg born in Ghent

Deaths

• Emperor Go-Tsuchimikado of Japan